Overview
Lori is named in Trailer 2 as Brian's wife. The trailer's framing places her inside the smuggling operation rather than separate from it: she works at the boat yard and handles weapons stored on-site.
Role in the story
Pre-launch details about Lori beyond her family ties and her place in the boat yard have not been released by Rockstar.
Trivia
IGN's breakdown notes she is described as Brian's third wife, framing her as a long-tenured Keys figure rather than a newcomer to the crew.